Publications
Peer-reviewed science.
2026
Efficacy, safety, and tolerability of arbaclofen in Autistic children and adolescents, the AIMS-2-TRIALS-CT1: a randomized, double-blind, placebo-controlled phase II trial.
Parellada M, et al. EClinicalMedicine
2021
A Phase II Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy, Safety, and Tolerability of Arbaclofen Administered for the Treatment of Social Function in Children and Adolescents With Autism Spectrum Disorders: Study Protocol for AIMS-2-TRIALS-CT1.
Parellada M, et al. Frontiers in Psychiatry
2018
R-baclofen reverses cognitive deficits and improves social interactions in two lines of 16p11.2 deletion mice.
Stoppel LJ, et al. Neuropsychopharmacology
2017
Arbaclofen in fragile X syndrome: results of phase 3 trials.
Berry-Kravis E, et al. J Neurodevelopmental Disorders
2016
Arbaclofen in Children and Adolescents with Autism Spectrum Disorder: A Randomized, Controlled, Phase 2 Trial.
Veenstra-VanderWeele JM, et al. Neuropsychopharmacology
View publication2014
STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study.
Erickson CA, et al. J Autism Dev Disord
2012
Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: A randomized, controlled, Phase 2 trial.
Berry-Kravis E, et al. Science Translational Medicine
2012
Reversal of disease phenotypes in the Fragile X mouse model by selective activation of GABA-B receptors.
Henderson C, et al. Science Translational Medicine
2008
The Autistic Neuron: Troubled Translation?
Kelleher RJ, Bear MF. Cell
2008
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.
Chang S, et al. Nat Chem Biol
2004
The mGluR theory of Fragile X mental retardation.
Bear MF, Huber KM, Warren ST. Trends in Neuroscience
Resources
Advocacy organizations.
Fragile X Syndrome
Autism Spectrum Disorder
Partnership
Let's bring arbaclofen to the patients and families who need it.
Partner with Allos to accelerate the first disease-modifying treatment for ASD and Fragile X Syndrome.